Jintropin 10IUSubstance: HGH, somatotropine
Delivery: 10 IU/vial
Manufacturer: China, GenSci
As with no other doping drug, growth hormones
are still surrounded by an aura of mystery. Some call it a
wonder drug which causes gigantic strength and muscle gains in
the shortest time. Others consider it completely useless in
improving sports performance and argue that it only promotes
the growth process in children with an early stunting of
growth. Some are of the opinion that growth hormones in adults
cause severe bone deformities in the form of overgrowth of the
lowerjaw and extremities. And, generally speaking, which
growth hormones should one take the human form, the
synthetically manufactured version, recombined or genetically
produced form and in which dosage? All this controversy about
growth hormones is so complex that the reader must have some
basic information in order to understand them. The growth
hormones is a polypeptide hormone consisting of 191 amino
acids. In humans it is produced in the hypophysis and released
if there are the right stimuli (e.g. training, sleep, stress,
low blood sugar level). It is now important to understand that
the freed HGH (human growth hormones) itself has no direct
effect but only stimulates the liver to produce and release
insulin-like growth factors and somatomedins. These growth
factors are then the ones that cause various effects on the
body. The problem, however, is that the liver is only capable
of producing a limited amount of these substances so that the
effect is limited. If growth hormones are injected they only
stimulate the liver to produce and release these substances
and thus, as already mentioned, have no direct effect. The use
of these STH somatotropic hormone compounds offers the athlete
three performance-enhancing effects. STH (somatotropic
hormone) has a strong anabolic effect and causes an increased
protein synthesis which manifests itself in a muscular
hypertrophy (enlargement of muscle cells) and in a muscular
hyperplasia (increase of muscle cells.) The latter is very
interesting since this increase cannot be obtained by the
intake of steroids. This is probably also the reason why STH
is called the strongest anabolic hormone. The second effect of
STH is its pronounced influence on the burning of fat. It
turns more body fat into energy leading to a drastic reduction
in fat or allowing the athlete to increase his caloric intake.
Third, and often overlooked, is the fact that STH strengthens
the connective tissue, tendons, and cartilages which could be
one of the main reasons for the significant increase in
strength experienced by many athletes. Several bodybuilders
and powerlifters report that through the simultaneous intake
with steroids STH protects the athlete from injuries while
inereasing his strength.
You will say that this sounds just
wonderful. What is the problem, however since there are still
some who argue that STH offers nothing to athletes? There are,
by all means, several athletes who have tried STH and who were
sadly disappointed by its results. However, as with many
things in life, there is a logical explanation or perhaps even
more than one:
1. The athlete simply has not taken a
sufficient amount of STH regularly and over a long enough
period of time. STH is a very expensive compound and an
effective dosage is unaffordable by most people.
2. When
using STH the body also needs more thyroid hormones,insulin,
corticosteroids, gonadotropins, estrogens and what a surprise
androgens and anabolics. This is also the reason why STH, when
taken alone, is considerably less effective and can only reach
its optimum effect by the additive intake of steroids, thyorid
hormones, and insulin, in particular. But we must point out in
this case that STH has a predominantly anabolic effect. There
are three hormones which are needed at the same time in order
to allow for maximum anabolic effect. These are STH, insulin,
and an LT-3 thyroid hormone, such as, for example, Cytomel.
Only then can the liver produce and release an optimal amount
of somatomedin and insulin-like growth factors. This anabolic
effect can be further enhanced by taking a substance with an
anticatabolic effect. These substances are-everybody should
probably know by now-anabolic/androgenic steroids or
Clenbuterol. Then a synergetic effect takes place.'Are you
still wondering why pro bodybuilders are so incredibly massive
but, at the same time, totally ripped while you are not. Most
athletes have tried STH during preparation for a competition
in that phase when the diet is calorie-reduced. The body
usually reacts by reducing the release of insulin and of the
L-T3 thyroid hormone. And, as was described under point 2,
this is not an advantageous condition when STH is expected to
work well. Well, we almost forgot. Those who combine
Clenbuterol with STH, should know that Clenbuterol (like
Ephedrine) reduces the body's own release of insulin and L-T3.
True, this seems a little complicated and when reading it for
the first time it might be a little confusing; however it
really is true: STH has a significant influence on several
hormones in the human body; this does not allow for a simple
administration schedule. As said, STH is not cheap and those
who intend to use it should know a little more about it. If
you only want to burn fat with STH you will only have to
remember user information for the part with the L-T3 thyroid
hormone as is printed by Kabi Pharmacia GmbH for their
compound Genotropin: "The need of the thyroid hormone often
inereases during treatment with growth hormones."
3. Since
most athletes who want to use STH can only obtain it if
prescribed by a physician, the only supply source remains the
black market. And this is certainly another reason why some
athletes might not have been very happy with the effect of the
purchased compound. How could he, if cheap HCG was passed off
as expensive STH? Since both compounds are available as dry
substances, all that would be needed is a new label of
Serono's Saizen or Lilly's Humatrope on the HCG ampule. It is
no longer fun when somebody is paying $200 for 5000 I.U. of
HCG, only worth $ 12, and thinking that he just purchased 4
I.U. of STH. And if you think this happens only to novices and
to the ignorant, ask Ben Johnson. "Big Ben," who during three
tests within five days showed an above-limit testosterone
level, was not a victim of his own stupidity but more likely
the victim of fraud. According to statistics by the German
Drug Administration, 42% of the HGH vials confiscated on the
North American black market are fakes. In addition to a
display of labels in the Dutch or Russian language the fakes
are distinguished from the original product, in sofar as the
dry substance is not present as lyophilic but present as loose
powder. The fakes confiscated so far use the name "Humatrope
16" under the name of Lilly Company (with Dutch denomination)
or "Somatogen" (in Russian)." Nowhere can this much money be
made except by faking STH. Who has ever held original growth
hormones in his hand and known how they should look?
4. In
a few very rare cases the body reacts by developing antibodies
to the exogenous STH, thus making it ineffective.
The
question of the right dosage, as well as the type and duration
of application, is very difficult to answer. Since there is no
scientificresearch showing how STH should be taken for
performance improvement, we can only rely on empirical data,
that is experimental values. The respective manufacturers
indicate that in cases of hypophysially stunted growth due to
lacking or insuffieient release of growt hormones by the
hypophysis, a weekly average dose of 0.3 I.U/ week per pound
of body weight should be taken. An athlete weighting 200
pounds, therefore, would have to inject 60 I.U. weekly. The
dosage would be divided into three intramuscular injections of
20 I.U. each. Subcutaneous injections (under the skin) are
another form of intake which, however would have to be
injected daily, usually 8 I.U. per day. Top athletes usually
inject 4-16 I.U./day. Ordinarily, daily subcutaneous
injections are preferred. Since STH has a half life time of
less than one hour, it is not surprising that some athletes
divide their dail dose into three or four subcutaneous
injections of 2-4 I.U. each. Application of regular small
dosages seems to bring the most effective results. This also
has its reasons: When STH is injected, serum concentration in
the blood rises quickly, meaning that the effect is almost
immediate. As we know, STH stimulates the liver to produce and
release somatomedins and insulin like growth factors which in
turn effect the desired results in the body. Since the liver
can only produce a limited amount of these substances, we
doubt that larger STH injections will induce the liver to
produce instantaneously a larger quantity of somatomedins and
insulin-like growth factors. It seems more likely that the
liver will react more favorably to smaller dosages. If the STH
solution is injected subcutaneously several consecutive times
at the same point of injection, a loss of fat tissue is
possible. Therefore, the point of injection, or even better,
the entire sisde of the body should be continuously, changed
in order to avoid a loss of local fat tissue (lipoathrophy) in
the injection cell. One thing has manifested itself over the
years: The effect of STH is dosage-dependent. This means
either invest a lot of money and do it right or do not even
begin. Half-hearted attempts are condemned to failure Minimum
effective dosages seem to start at 4 I.U. per day. For
comparison: the hypophysis of a healthy; adult, releases
0.5-1.5 I.U. growth hormones daily. The duration of intake
usually depends on the athlete's financial resources. Our
experience is that STH is taken over a prolonged period, from
at least six weeks to several months. It is interesting to
note that the effect of STH does not stop after a few weeks;
this usually allows for continued improvements at a steady
dosage. Bodybuilders who have had positive results with STH
have reported that the build-up strength and, in particular,
the newly-gained muscle system were essentially maintained
after discontinuance of the product. It remains to be
clarified what happens with the insulin and LT-3 thyroid
hormone. Athletes who take STH in their build-up phase usually
do not need exogenous insulin. It is recommended, in this
case, that the athlete eats a complete meal every three hours,
resulting in 6-7 meals day. This causes the body to
continuously release insulin so that the blood sugar level
does not fall too low. The use of LT-3 thyroid hormones, in
this phase, is carried out reluctantly by athletes. In any
case, you must have a physician check the thyroid hormone
level during the intake of STH. Simultaneous use of anabolic
/androgenic steroids and/or Clenbuterol is usually
appropriate. During the preparation for a competition the use
of thyroid hormones steadily inereases. Sometimes insulin is
taken together with STH, as well as with steroids and
Clenbuterol. Apart from the high damage potential that
exogenous insulin can have in non-diabetics, incorrect use
will simply and plainly make you "FAT! Too much insulin
activates certain enzymes which convert glucose into glycerol
and finally into triglyceride. Too little insulin, especially
during a diet, reduces the anabolic effect of STH. The
solution to this dilemma? Visiting a qualified physician who
advises the athlete during this undertaking and who, in the
event of exogenous insulin supply, checks the blood sugar
level and urine periodically. According to what we have heard
so far, athletes usually inject intermediately-effective
insulin having a maximum duration of effect of 24 hours once a
day. Human insulin such as Depot-H-Insulin Hoechst is
generally used. Briefly-effective insulin with a maximum
duration of effect of eight hours is rarely used by athletes.
Again a human insulin such as H-Insulin Hoechst is
preferred.
The undesired effect of growth hormones, the
so-called side effects, are also a very interesting and
hotly-discussed issue. Above all it must be said: STH has none
of the typical side effects of anabolic/androgenic steroids
including reduced endogenous testosterone production, acne,
hair loss, aggressiveness, elevated estrogen level,
virilization symptoms in women, and increased water and salt
retention. The main side effects that are possible with STH
are an abnormally small concentration of glucose in the blood
(hypoglycemia) and an inadequate thyroid function. In some
cases antibodies against growth hormones are developed but are
clinically irrelevant. What about the horror stories about
acromegaly, bone deformation, heart enlargement, organ
conditions, gigantism, and early death? In order to answer
this question a clear differentiation must be made between
humans before and after puberty. The growth plates in a person
continue to grow in length until puberty. After puberty
neither an endogenous hypersection of growth hormones nor an
excessive exogenous supply of STH can cause additional growth
in the length of the bones. Abnormal size (gigantism)
initially goes hand in hand with remarkable body strength and
muscular hardness in the afflicted; later, if left untreated,
it ends in weakness and death. Again, this is only possible in
pre-pubescent humans who also suffer from an inadequate
gonadal function (hypogonadism). Humans who suffer from an
endogenous hypersecrehon after puberty and whose normal growth
is completed can also suffer from acromegaly. Bones become
wider but not longer. There is a progressive growth in the
hands and feet and enlargement of features due to the growth
of the lower jaw and nose. What the authorities like to do now
is to present extreme cases of athletes suffering from these
malfunctions in order to discourage others and to drum into
athletes the fact that with the exogenous supply of growth
hormones they would suffer the same destiny. This, however, is
very unlikely, as reality has proven. Among the numerous
athletes using STH comparatively few are seven feet tall
Neanderthalers with a protruded lower jaw, deformed skull,
claw like hands, thick lips, and prominent bone plates who
walk around in size 25 shoes. In order to avoid any
misunderstandings, we do not want to disguise the possible
risks of exogenous STH use in adults and healthy humans, but
one should at least try to be openminded. Acromegaly,
diabpetes, thyroid insuficiency, heart muscle hypertrophy,
high blood ressure, and enlargement of the kidneys are
theoretically possible if STH is used excessively over
prolonged periods of time; however, in reality and
particularly when it comes to the external attributes, these
are rarely present. Some athletes report headaches, nausea,
vomiting, and visual disturbances during the first weeks of
intake. These symptoms disappear in most cases even with
continued intake. The most common problems with STH occur when
the athlete intends to inject insulin in addition to STH. The
substance somatropin is available as a dried powder and before
injecting it must be mixed with the enclosed
solution-containing ampule. The ready solution must be
injected immediately or stored in the refrigerator for up to
24 hours. It is usually recommended that the compound be
stored in the refrigerator. With the exception of the remedy
Saizen the biological activity of growth hormones is usually
not impaired when storing the dry substance at 15-25 C (room
temperature); however, a cooler place (2-8° C) is preferable.
It is noted that for the U.S.-American growth hormones
compounds, the substance content is not given in
I.U.(International Units) but in mg (milligrams). Since l mg
corresponds to exactly 2.7 I.U. the 5mg solution of the
compound Humatrope by Lilly contains exactl 13.5 I.U. of
Somatropin. The 10 mg solution of the Protropin compound by
the Genentech therefore contains 27 I.U. of Somatropin. In
American powerlifting and bodybuilding circles Humatrope is
usually preferred over Protropin. The reason is that Humatrope
is synthesized from a chain of 191 amino acids and thus is
identical to the amino acid sequence of the human growth
hormones. Protropin, on the other hand, consists of 192 amino
acids, one amino acid too many. This might be the explanation
for why more antibodies are developed with Protropin than with
Humatrope. Growth hormones are on the doping list but they are
not yet detectable during doping tests.
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